Platelet‐derived transforming growth factor‐β1 promotes keratinocyte proliferation in cutaneous wound healing

Activation of keratinocyte fibronectin receptor function during cutaneous wound healing.

Keratinocytes freshly isolated from unwounded skin could not attach and spread on fibronectin (FN)-coated culture dishes and could not bind and phagocytose FN-coated beads. These adhesive functions were activated, however, in keratinocytes that were isolated from healing wounds. Moreover, adhesiveness of basal keratinocytes to FN substrata was activated during epidermal cell or explant culture....

Signaling Pathway Proliferation and Migration via the ERK Healing by Promoting Keratinocyte Adiponectin Regulates Cutaneous Wound

Recombinant Keratinocyte Growth Factor 1 in Tobacco Potentially Promotes Wound Healing in Diabetic Rats

Keratinocyte growth factor 1 (KGF1) is a growth factor that promotes epidermal cell proliferation, migration, differentiation, and wound repair. It is expressed at low levels in a form of inclusion body in E. coli. In order to increase its expression and activity, we produced tobacco plants expressing KGF1 via Agrobacterium-mediated transformation using a potato virus X (PVX)-based vector (pgR1...

Complement deficiency promotes cutaneous wound healing in mice.

Wound healing is a complex homeostatic response to injury that engages numerous cellular activities, processes, and cell-to-cell interactions. The complement system, an intricate network of proteins with important roles in immune surveillance and homeostasis, has been implicated in many physiological processes; however, its role in wound healing remains largely unexplored. In this study, we emp...

Curcumin Enhanced Cutaneous Wound Healing by Modulating Cytokines and Transforming Growth Factor in Excision Wound Model in Rats

Cutaneous wounds are physical injuries that result in an opening or break of the skin that causes disturbances in the normal skin anatomy & function (Strodtbeck, 2001). It is an orchestrated series of events that includes inflammation, cell migration, cell proliferation, angiogenesis, matrix deposition and tissue remodeling (Gurtner et al., 2008; Braiman-Wiksman et al., 2007). There are many cy...